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2093386-23-1

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2093386-23-1 Structure

2093386-23-1 Structure
IdentificationBack Directory
[Name]

Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester
[CAS]

2093386-23-1
[Synonyms]

Thalidomide-NH-CH2-COO(t-Bu)
tert-Butyl (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycinate
Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester
[Molecular Formula]

C19H21N3O6
[MOL File]

2093386-23-1.mol
[Molecular Weight]

387.39
Chemical PropertiesBack Directory
[Boiling point ]

608.3±55.0 °C(Predicted)
[density ]

1.397±0.06 g/cm3(Predicted)
[pka]

10.73±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

Thalidomide-NH-CH2-COO (t-Bu) is a ligand for E3 ubiquitin ligase PROTAC BET Degrader-1 (HY-103633)[1].
[IC 50]

Cereblon
[References]

[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816
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