| Identification | Back Directory | [Name]
Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester | [CAS]
2097509-40-3 | [Synonyms]
Thalidomide-NH-PEG2-NH-Boc
Thalidomide-4-NH-PEG2-NH-Boc
Thalidomide-NH-PEG2-C2-NH-Boc
tert-butyl (2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)carbamate
Carbamic acid, N-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C24H32N4O8 | [MOL File]
2097509-40-3.mol | [Molecular Weight]
504.53 |
| Chemical Properties | Back Directory | [Boiling point ]
734.4±60.0 °C(Predicted) | [density ]
1.323±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.74±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized?E3 ligase ligand-linker conjugate?that incorporates the?Thalidomide?based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1]. | [IC 50]
Cereblon | [References]
[1] David Remillard, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.2017 May 15;56(21):5738-5743. DOI:10.1002/anie.201611281 |
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