| Identification | Back Directory | [Name]
9H-Pyrimido[4,5-b]indole-2-carboxylic acid, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-6-methoxy- | [CAS]
2093387-77-8 | [Synonyms]
9H-Pyrimido[4,5-b]indole-2-carboxylic acid, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-6-methoxy- | [Molecular Formula]
C25H25N7O4 | [MOL File]
2093387-77-8.mol | [Molecular Weight]
487.51 |
| Chemical Properties | Back Directory | [Boiling point ]
783.1±70.0 °C(Predicted) | [density ]
1.59±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.70±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PROTAC BET-binding moiety 1 is a key intermediate for the synthesis of high-affinity BET inhibitors[1]. | [References]
[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816 |
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