2093408-03-6

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2093408-03-6 Structure

Identification	Back Directory
[Name] INDEX NAME NOT YET ASSIGNED
[CAS] 2093408-03-6
[Synonyms]
[Molecular Formula] C30H49N9O6
[MOL File] 2093408-03-6.mol
[Molecular Weight] 631.78

Chemical Properties	Back Directory
[density ] 1.43±0.1 g/cm3(Predicted)
[solubility ] Soluble to 2 mg/ml in 0.1% acetic acid
[pka] 12.09±0.46(Predicted)

Hazard Information	Back Directory
[Description] AY 254 is a potent PAR2 biased agonist. It selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release). AY 254 reduces cytokine-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cells in vitro.
[Uses] AY254 is an analogue of AY77 (HY-138951). AY254 is ERK-biased PAR2 agonist with an EC50 of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling[1]
[IC 50] PAR2: 2 nM (EC₅₀)
[storage] Store at -20°C
[References] [1] Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12(5):1217-1226. DOI:10.1021/acschembio.6b01088

2093408-03-6 suppliers list

Company Name:	Beijing Biocreative Technology Co., Ltd.
Tel:	15522676233
Website:	www.bestbaiao.com/

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