| Chemical Properties | Back Directory | [density ]
1.30±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
12.90±0.46(predicted) | [Sequence]
Ac-Leu-Gln-Thr-Leu-Arg-X-Ile-Gln-Arg-X-Leu-NH2 (X=(S)-2-(4'-pentenyl)-Ala) |
| Hazard Information | Back Directory | [Uses]
hsBCL9CT-24 is a Wnt/β-catenin (b-cat) pathway inhibitor with potent anti-tumor effect. hsBCL9CT-24 reactivates anti-cancer immune response suppressed by the oncogenic Wnt pathway and can be utilized for cancer research[1]. | [References]
[1] Feng M, et al. Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells. Sci Adv. 2019 May 8;5(5):eaau5240. DOI:10.1126/sciadv.aau5240 |
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