| Identification | Back Directory | [Name]
PROTAC IAP binding moiety 2 | [CAS]
2095244-62-3 | [Synonyms]
MV-1-NH-Me
PROTAC IAP binding moiety 2
(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-[(2S)-1-(methylamino)-1-oxo-3,3-diphenylpropan-2-yl]pyrrolidine-2-carboxamide | [Molecular Formula]
C33H45N5O4 | [MDL Number]
MFCD32062716 | [Molecular Weight]
575.74 |
| Hazard Information | Back Directory | [Uses]
MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER[1]. | [IC 50]
cIAP1 | [References]
[1] Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. DOI:10.1111/cas.13284 |
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