| Identification | Back Directory | [Name]
E3 ligase Ligand 10 | [CAS]
1073560-68-5 | [Synonyms]
E3 ligase Ligand 10
(S)-2-((S)-1-((S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)propanamido)-2-cyclohexylacetyl)pyrrolidine-2-carboxamido)-3,3-diphenylpropanoic acid | [Molecular Formula]
C47H52N4O7 | [MDL Number]
MFCD32197258 | [MOL File]
1073560-68-5.mol | [Molecular Weight]
784.94 |
| Hazard Information | Back Directory | [Uses]
E3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1]. | [IC 50]
IAP | [References]
[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
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