| Identification | Back Directory | [Name]
SAG hydrochloride | [CAS]
2095432-58-7 | [Synonyms]
SAG.2HCl
SAG hydrochloride
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(4-pyridinyl)benzyl]-1-benzothiophene-2-carboxamide hydrochloride (1:1)
Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-, hydrochloride (1:1) | [Molecular Formula]
C28H29Cl2N3OS | [MOL File]
2095432-58-7.mol | [Molecular Weight]
526.52 |
| Hazard Information | Back Directory | [Uses]
The hydrochloride form of SAG (S083600), a chlorobenzothiophene-containing Hh pathway agonist, which binds to the Smo heptahelical bundle and antagonizes cyclopamine action. | [in vivo]
SAG (1.0 mM) induces more osteogenesis mainly at the defect borders and a significant increase in BV/TV at the eight week timepoint in CD-1 mice[4].
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SAG (15-20 mg/kg; i.p.) induces pre-axial polydactyly prevalently in a dose-dependent manner in mice[5]. | Animal Model: | Pregnant C57BL/6J mice[5] | | Dosage: | 15, 17, 20 mg/kg | | Administration: | A single i.p. | | Result: | Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg. |
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| Company Name: |
Twochem Co.Ltd.
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| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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