| Identification | Back Directory | [Name]
N-Mal-N-bis(PEG2-NH-Boc) | [CAS]
2128735-26-0 | [Synonyms]
N-Mal-N-bis(PEG2-NH-Boc)
5,8,14,17-Tetraoxa-2,11,20-triazaheneicosanedioic acid, 11-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-, 1,21-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C29H50N4O11 | [MDL Number]
MFCD31536763 | [MOL File]
2128735-26-0.mol | [Molecular Weight]
630.73 |
| Hazard Information | Back Directory | [Description]
N-Mal-N-bis(PEG2-NH-Boc) is a branched maleimide reagent with a terminal maleimide group and two terminal Boc protected amino groups. Maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule . Boc can be deprotected under acidic conditions. | [Uses]
N-Mal-N-bis(PEG2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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