| Identification | Back Directory | [Name]
N-(Propargyl-PEG2)-N-bis(PEG1-alcohol) | [CAS]
2100306-62-3 | [Synonyms]
Propargyl-PEG2-N-bis(PEG2)
N-(Propargyl-PEG2)-N-bis(PEG1-alcohol) | [Molecular Formula]
C15H29NO6 | [MDL Number]
MFCD30723221 | [MOL File]
2100306-62-3.mol | [Molecular Weight]
319.39 |
| Chemical Properties | Back Directory | [Boiling point ]
440.2±40.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
14.10±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Propargyl-PEG2)-N-bis(PEG1-alcohol) is a multi-arm linker that can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. | [Uses]
Propargyl-PEG2-N-bis(PEG2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-N-bis(PEG2) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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