| Identification | Back Directory | [Name]
Hydroxy-Amino-bis(PEG2-propargyl) | [CAS]
2100306-77-0 | [Synonyms]
Hydroxy-Amino-(PEG2-propargyl)2
Hydroxy-Amino-bis(PEG2-propargyl)
Ethanol, 2-[bis[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]amino]- | [Molecular Formula]
C16H27NO5 | [MDL Number]
MFCD30723249 | [MOL File]
2100306-77-0.mol | [Molecular Weight]
313.39 |
| Hazard Information | Back Directory | [Description]
Hydroxy-Amino-bis(PEG2-propargyl) is a 3-arm linker with a terminal hydroxy group and two propargyl groups. The propargyl groups can participate in copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. | [Uses]
Hydroxy-Amino-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Hydroxy-Amino-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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