| Identification | Back Directory | [Name]
5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 14-(2,3,4,5,6-pentafluorophenyl) ester | [CAS]
2101206-48-6 | [Synonyms]
BCOT-PEF3-OPFP
5,8,11-Trioxa-2-azatetradecanedioic acid, 1-(bicyclo[6.1.0]non-4-yn-9-ylmethyl) 14-(2,3,4,5,6-pentafluorophenyl) ester | [Molecular Formula]
C26H30F5NO7 | [MOL File]
2101206-48-6.mol | [Molecular Weight]
563.51 |
| Hazard Information | Back Directory | [Uses]
BCOT-PEF3-OPFP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCOT-PEF3-OPFP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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