| Identification | Back Directory | [Name]
SHMT-IN-2 | [CAS]
2102681-49-0 | [Synonyms]
SHIN2
SHMT-IN-2
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-2,4-dihydro-3-methyl-4-(1-methylethyl)-4-[3-(1-pyrrolidinyl)-5-(trifluoromethyl)phenyl]- | [Molecular Formula]
C22H24F3N5O | [MOL File]
2102681-49-0.mol | [Molecular Weight]
431.45 |
| Chemical Properties | Back Directory | [Boiling point ]
621.2±55.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (231.78 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.77±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas[1]. | [storage]
4°C, protect from light | [References]
[1] regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. DOI:10.1073/pnas.1706617114 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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