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330638-43-2

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330638-43-2 Structure

330638-43-2 Structure
IdentificationBack Directory
[Name]

Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI)
[CAS]

330638-43-2
[Synonyms]

SHMT inhibitor Hit 1
Butanoic acid, 4,4'-[2,4-pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo- (9CI)
[Molecular Formula]

C24H22N4O6
[MOL File]

330638-43-2.mol
[Molecular Weight]

462.45
Chemical PropertiesBack Directory
[Boiling point ]

787.0±60.0 °C(Predicted)
[density ]

1.410±0.06 g/cm3(Predicted)
[pka]

4.50±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

SHMT-IN-3 (Hit 1) is a SHMT1 and SHMT2 inhibitor with an IC50 of 0.53?μM for human SHMT1. SHMT-IN-3 exhibits noncompetitive inhibition against serine[1].
[IC 50]

Human SHMT1: 0.53 μM (IC50)
[References]

[1] Hiroshi Nonaka, et al. Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction. Nat Commun. 2019 Feb 20;10(1):876. DOI:10.1038/s41467-019-08833-7
330638-43-2 suppliers list
Company Name: Shaoyuan Technology (Shanghai) Co., Ltd.  
Telephone: 021-50795510 4000665055
Website: https://www.shao-yuan.com
Company Name: TargetMol  
Telephone: 400-821-0310 15002144251
Website: www.targetmol.cn/
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