| Identification | Back Directory | [Name]
GSK-CXCR2 | [CAS]
211096-49-0 | [Synonyms]
GSK-CXCR2
SB 265610
SB265610 >=98% (HPLC)
N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-
1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea | [Molecular Formula]
C14H9BrN6O | [MDL Number]
MFCD09971124 | [MOL File]
211096-49-0.mol | [Molecular Weight]
357.16 |
| Chemical Properties | Back Directory | [Boiling point ]
527.0±45.0 °C(Predicted) | [density ]
1.77±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble15mg/mL, clear | [form ]
powder | [pka]
6.13±0.40(Predicted) | [color ]
white to light brown | [InChI]
1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21) | [InChIKey]
SEDUMQWZEOMXSO-UHFFFAOYSA-N | [SMILES]
Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23 |
| Hazard Information | Back Directory | [Uses]
SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist. | [Biological Activity]
Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo . | [Biochem/physiol Actions]
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM. | [in vivo]
SB-265610 (2 mg/kg/day; i.p.; daily; for two weeks) treatment significantly inhibits the recruitment of Gr-1+CD11b+ cells to the mammary adenocarcinoma with Tgfbr2 deletion but not the control tumors[3]. | Animal Model: | MMTV-PyVmT/Tgfbr2MGKO and MMTV-PyVmT/Tgfbr2flox/flox tumors from donor mice[3] | | Dosage: | 2 mg/kg/day
| | Administration: | Intraperitoneal injection; daily; for two weeks | | Result: | Significantly inhibited the recruitment of Gr-1+CD11b+ cells to the mammary adenocarcinoma. |
| [IC 50]
CXCR2 | [storage]
Store at RT |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|