| Identification | Back Directory | [Name]
SB 200646 HYDROCHLORIDE | [CAS]
143797-63-1 | [Synonyms]
SB 200646
SB200646HCl
SB 200646 HYDROCHLORIDE
N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea
N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
1-(1-Methyl-1H-indol-5-yl)-3-pyridin-3-yl-urea
Urea, N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl-
N-(1-METHYL-1H-INDOL-5-YL)-N'-3-PYRIDINYLUREA HYDROCHLORIDE
N-(1-METHYL-1H-5-INDOLYL)-N'-(3-PYRIDINYL)UREA HYDROCHLORIDE | [Molecular Formula]
C15H14N4O | [MOL File]
143797-63-1.mol | [Molecular Weight]
266.3 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C
| [solubility ]
DMSO: ~26 mg/mL, soluble
| [form ]
solid
| [color ]
pale yellow
| [Water Solubility ]
Water: 1 mg/mL (NaN mM) |
| Hazard Information | Back Directory | [Uses]
SB 200646 Hydrochloride is a 5-HT2C antagonist. | [Definition]
ChEBI: SB 200646 is a member of indoles. | [Biological Activity]
5-HT 2C/2B receptor antagonist, selective over 5-HT 1A . Affinities are 7.4 (pA 2 ), 6.9 (pK i ) and 5.2 (pK i ) for 5-HT 2B , 2C and 2A respectively. Orally active in vivo . | [in vivo]
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1]. | Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1] | | Dosage: | 20 mg/kg | | Administration: | Intravenous injection; daily; for 21 days | | Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
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| [IC 50]
5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi) |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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