| Identification | Back Directory | [Name]
Mal-amido-PEG7-acid | [CAS]
2112731-42-5 | [Synonyms]
Mal-NH-PEG7-acid
Mal-NH-PEG7-COOH
Mal-amido-PEG7-COOH
Mal-amido-PEG7-acid
Mal-amido-PEG7-propionic acid
1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25-heptaoxa-4-azaoctacosan-28-oic acid
4,7,10,13,16,19,22-Heptaoxa-25-azaoctacosanoic acid, 28-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-26-oxo- | [Molecular Formula]
C24H40N2O12 | [MDL Number]
MFCD30723255 | [MOL File]
2112731-42-5.mol | [Molecular Weight]
548.58 |
| Hazard Information | Back Directory | [Uses]
Mal-amido-peg7-acid is a useful research chemical, a PEG linker and a PEG reagent. | [Biological Activity]
Mal-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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