| Identification | Back Directory | [Name]
alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol) | [CAS]
756525-99-2 | [Synonyms]
N-Succinim
Mal-PEG4-NHS
Mal-NH-PEG4-NHS
Mal-amido-PEG4-NHS
MAL-DPEG4-NHS Ester
Mal-NH-PEG4-NHS ester
MAL-NH-PEG4-CH2CH2COONHS
Maleimide-PEG4-NHS Ester
Maleimide-PEG4-succinimidyl Ester
Maleimide-NH-PEG4-CH2CH2COONHS Ester
Maleimidopropionyl-PEG4-CH2CH2COONHS Ester
alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol)
3-(2-Maleimidoethylcarbamoyl)-peg4-propionic acid N-hydroxysuccinimide ester
O-[N-(3-MaleiMidopropionyl)aMinoethyl]-O′-[3-(N-succiniMidyloxy)-3-oxopropyl]triethylene glycol
O-[N-(3-Maleimidopropionyl)aminoethyl]-O'-[3-(N-succinimidyloxy)-3-oxopropyl]triethylene glycol >=90% (NMR)
2,5-dioxopyrrolidin-1-yl 19-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-17-oxo-4,7,10,13-tetraoxa-16-azanonadecan-1-oate
2,5-dioxopyrrolidin-1-yl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oate
N-[15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-2,5-dihydro-2,5-dioxo-1H-pyrrole-1-propanamide
4,7,10,13-Tetraoxa-16-azanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | [EINECS(EC#)]
201-258-5 | [Molecular Formula]
C22H31N3O11 | [MDL Number]
MFCD11041113 | [MOL File]
756525-99-2.mol | [Molecular Weight]
513.49 |
| Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
15.01±0.46(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C22H31N3O11/c26-17(5-8-24-18(27)1-2-19(24)28)23-7-10-33-12-14-35-16-15-34-13-11-32-9-6-22(31)36-25-20(29)3-4-21(25)30/h1-2H,3-16H2,(H,23,26) | [InChIKey]
XSRYGQJQNPJNKZ-UHFFFAOYSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O |
| Hazard Information | Back Directory | [Description]
Mal-amido-PEG4-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Uses]
Maleimide-PEG4-NHS (CAS# 756525-99-2) is a cross-linking compound used in the lysosomal acid-triggered release of anticancer drugs. | [General Description]
Maleimide-PEG4-NHS Ester (CAS 756525-99-2) is a high-purity, monodisperse polyethylene glycol (PEG) derivative. Its synonyms include Mal-amido-PEG4-NHS, Mal-amido-PEG4-NHS ester, Mal-NH-PEG4-NHS, MAL-NH-PEG4-NHS ESTER and Mal-NH-PEG4-CH₂CH₂COONHS, amongst others. This compound possesses three key functional groups: the Mal group, the PEG4 chain and the NHS ester. The Mal group is capable of forming covalent bonds with thiol groups without affecting the overall structure of the protein; the NHS ester enhances reactivity with primary amine groups, facilitating the formation of stable amide bonds; whilst PEG4 improves the hydrophilicity and biocompatibility of the conjugate, whilst also reducing aggregation and immunogenicity. Consequently, this substance is primarily used in the synthesis of protein conjugates, drug delivery research, diagnostic testing and materials science. | [reaction suitability]
reagent type: cross-linking reagent | [IC 50]
PEGs; Alkyl/ether |
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T&W GROUP
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021-61551611 13296011611 |
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www.trustwe.com/ |
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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