| Identification | Back Directory | [Name]
N-(Boc-PEG4)-NH-PEG4-t-butyl ester | [CAS]
2112737-17-2 | [Synonyms]
N-(Boc-PEG4)-NH-PEG4-NH-Boc
N-(Boc-PEG4)-NH-PEG4-t-butyl ester
5,8,11,14,20,23,26,29-Octaoxa-2,17-diazadotriacontanedioic acid, 1,32-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C30H60N2O12 | [MDL Number]
MFCD30730365 | [MOL File]
2112737-17-2.mol | [Molecular Weight]
640.8 |
| Hazard Information | Back Directory | [Description]
N-(Boc-PEG4)-NH-PEG4-t-butyl ester is a small molecule intermediate containing an amino group, a t-butyl ester and Boc protected amino group. The amino group can react with carboxylic acids, activated NHS esters, and carbonyls. The protected amine can be deprotected under acidic conditions. | [Uses]
N-(Boc-PEG4)-NH-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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