| Identification | Back Directory | [Name]
JC-171
(JC171) | [CAS]
2112809-98-8 | [Synonyms]
JC-171
(JC171)
Benzamide, 5-chloro-N-[2-[4-[(hydroxyamino)sulfonyl]phenyl]ethyl]-2-methoxy- | [Molecular Formula]
C16H17ClN2O5S | [MDL Number]
MFCD32708504 | [MOL File]
2112809-98-8.mol | [Molecular Weight]
384.83 |
| Chemical Properties | Back Directory | [density ]
1.401±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (649.64 mM) | [form ]
Solid | [pka]
6.43±0.69(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
JC-171 is a selective NLRP3 inflammasome inhibitor, with an IC50 of 8.45 μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages[1]. | [in vivo]
JC-171 treatment delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE) in mouse[1]. | Animal Model: | Mice immunized subcutaneously with 200 μg Myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide emulsified in Complete Freund’s Adjuvant (CFA) on day 0 followed by injection of 200 ng of pertussis toxin. | | Dosage: | 100 mg/kg, 10 mg/kg. | | Administration: | IP days 0, 1 and 2; and every other days thereafter (100 mg/kg).
Initiated when the clinical scores of individual mice have reached 1 (flaccid tail), and given every other day (10 mg/kg).
| | Result: | Efficiently suppressed EAE progression compared with vehicle treatment.
Resulted in a substantial decrease in the frequency of MOG35–55-specific Th17 cells in the spleens and spinal cords of EAE mice.
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| [IC 50]
NLRP3 | [storage]
Store at -20°C | [References]
[1] Chunqing Guo, et al. Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis. ACS Chem Neurosci. 2017 Oct 18;8(10):2194-2201. DOI:10.1021/acschemneuro.7b00124 |
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| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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