| Chemical Properties | Back Directory | [Boiling point ]
573.3±50.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.86±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
WNK-IN-7 is a potent and selectiive inhibitor of WNK1 kinase. | [Uses]
WNK-IN-1 (compound 7) is a ATP noncompetitive With-No-Lysine (WNK) kinase inhibitor (IC50=95 nM). WNK-IN-1 can be used to regulate cardiovascular homeostasis[1]. | [References]
[1] Yamada K, et al. Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. J Med Chem. 2017 Aug 24;60(16):7099-7107. DOI:10.1021/acs.jmedchem.7b00708 |
|
|