| Identification | More | [Name]
2,2'-Dithiodipyridine | [CAS]
2127-03-9 | [Synonyms]
2,2'-DIPYRIDYL DISULFIDE
2,2'-DIPYRIDYL DISULPHIDE
2,2'-DITHIODIPYRIDINE
2-(PYRIDIN-2-YLDITHIO)PYRIDINE
2-PYRIDINYL DISULFIDE
ALDRITHIOL-2
ALDRITHIOL(TM)-2
2-(2-Pyridinyldisulfanyl)pyridine
2,2'-Dipyridinyl disulfide
2,2'-Dithiobis(pyridine)
2,2'-Dithiopyridine
2-Dipyridyl disulfide
2PDS
2-Pyridyl disulfide
Aldrithol-2
Bis(2-pyridinyl) disulfide
Bis(2-pyridyl) disulfide
Di-2-Pyridyl disulfide
Nsc 677438
Pyridine, 2,2'-dithiodi- | [EINECS(EC#)]
218-343-1 | [Molecular Formula]
C10H8N2S2 | [MDL Number]
MFCD00006287 | [Molecular Weight]
220.31 | [MOL File]
2127-03-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white to yellowish crystalline powder | [Melting point ]
56-58 °C(lit.)
| [Boiling point ]
356.1±17.0 °C(Predicted) | [density ]
1.3078 (rough estimate) | [refractive index ]
1.5500 (estimate) | [Fp ]
210 °C
| [storage temp. ]
2-8°C
| [solubility ]
methanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow | [form ]
powder
| [pka]
1.52±0.19(Predicted) | [color ]
Clear colorless to yellow to tan | [Water Solubility ]
5 g/L (20 ºC) | [BRN ]
154629 | [InChI]
1S/C10H8N2S2/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10/h1-8H | [InChIKey]
HAXFWIACAGNFHA-UHFFFAOYSA-N | [SMILES]
S(Sc1ccccn1)c2ccccn2 | [LogP]
2.530 (est) | [CAS DataBase Reference]
2127-03-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyridine, 2,2'-dithiobis-(2127-03-9) | [EPA Substance Registry System]
Pyridine, 2,2'-dithiobis- (2127-03-9) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R37:Irritating to the respiratory system.
R20/22:Harmful by inhalation and if swallowed . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection .
S25:Avoid contact with eyes .
S22:Do not breathe dust .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3335 | [WGK Germany ]
3
| [F ]
10-23 | [Autoignition Temperature]
340 °C | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to yellowish crystalline powder | [Uses]
2,2'-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols and activating or protecting carboxylic acid with triphenylphosphine. | [Definition]
ChEBI: Aldrithiol is a member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols. It has a role as an oxidising agent. It is an organic disulfide and a member of pyridines. | [General Description]
Aldrithiol?-2 is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1 virions. It is a thiol reagent. | [Biochem/physiol Actions]
2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives. | [Purification Methods]
Recrystallise the disulfide H2O from *C6H6/pet ether (6:7), ligroin or *C6H6. The picrate has m 119o (from EtOH). [Walter et al. Justus Liebigs Ann Chem 695 7785 1966, Marckwald et al. Chem Ber 33 1556 1900, Brocklehurst & Little Biochem J 133 67,78 1973, Beilstein 21 III/IV 48.] It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 2-mercaptopyridine anion, thereby shifting the from 340nm (of the disulfide) to 268nm (of the anion) at pH 9, or 278nm in H2O. (Compare |
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