| Identification | Back Directory | [Name]
AP1867-3-(Methoxyethylamine) | [CAS]
2127390-15-0 | [Synonyms]
Shield-1 analog
AP1867-3-(aminoethoxy)
AP1867-3-(Methoxyethylamine)
2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-1-[3-(2-aminoethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl ester, (2S)- | [Molecular Formula]
C38H50N2O9 | [MDL Number]
MFCD32215344 | [MOL File]
2127390-15-0.mol | [Molecular Weight]
678.81 |
| Chemical Properties | Back Directory | [Boiling point ]
793.4±60.0 °C(Predicted) | [density ]
1.169±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.48±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AP1867-3-(aminoethoxy), the AP1867 based moiety, is a synthetic ligand for FKBP. AP1867-3-(aminoethoxy) can be used in the synthesis of PROTAC FKBP12 F36V degrader[1]. | [References]
[1] Ottis P, et al. Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation. ACS Chem Biol. 2017 Oct 20;12(10):2570-2578. DOI:10.1021/acschembio.7b00485 |
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