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2136296-33-6

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2136296-33-6 Structure

2136296-33-6 Structure
IdentificationBack Directory
[Name]

Maleimide-NH-PEG12-CH2CH2COOPFP Ester
[CAS]

2136296-33-6
[Synonyms]

Mal-NH-PEG12-CH2CH2COOPFP ester
Maleimide-NH-PEG12-CH2CH2COOPFP Ester
[Molecular Formula]

C40H59F5N2O17
[MDL Number]

MFCD34470033
[MOL File]

2136296-33-6.mol
[Molecular Weight]

934.89
Chemical PropertiesBack Directory
[Boiling point ]

872.2±65.0 °C(Predicted)
[density ]

1.272±0.06 g/cm3(Predicted)
[pka]

15.01±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

Mal-NH-PEG12-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[Biological Activity]

Mal-NH-PEG12-CH2CH2COOPFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[IC 50]

PEGs
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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