| Identification | Back Directory | [Name]
diABZI STING agonist-1 Tautomerism | [CAS]
2138498-18-5 | [Synonyms]
diABZI STING agonist-1 Tautomerism
diABZI STING agonist 1 (compound 3)
1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[(2E)-5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-[3-(4-morpholinyl)propoxy]-, (2E)- | [Molecular Formula]
C42H51N13O7 | [MDL Number]
MFCD31746907 | [MOL File]
2138498-18-5.mol | [Molecular Weight]
849.94 |
| Chemical Properties | Back Directory | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
11.87±0.43(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Chemical Properties]
diABZI STING agonist-1 Tautomerism is a potent non-nucleoside STING agonist with great potential for the treatment of human cancers. | [Uses]
diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921) (compound 3). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively[1]. | [in vitro]
diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, it demonstrates high selectivity against more than 350 kinases tested. | [in vivo]
diABZI STING agonist-1 (Tautomerism) (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo. | [References]
[1] Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7. DOI:10.1038/s41586-018-0705-y |
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