| Identification | Back Directory | [Name]
KEA1-97 | [CAS]
2138882-71-8 | [Synonyms]
KEA1-97
KEA1-97 >=98% (HPLC)
1,3,5-Triazin-2-amine, 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)- | [Molecular Formula]
C15H9Cl2FN4 | [MDL Number]
MFCD31697744 | [MOL File]
2138882-71-8.mol | [Molecular Weight]
335.16 |
| Chemical Properties | Back Directory | [Boiling point ]
530.3±52.0 °C(Predicted) | [density ]
1.466±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO : 100 mg/mL (298.36 mM; Need ultrasonic) | [form ]
Solid | [pka]
0.57±0.10(Predicted) | [color ]
White to light yellow | [InChI]
InChI=1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22) | [InChIKey]
DUROVTLUQOYUPH-UHFFFAOYSA-N | [SMILES]
N1=C(Cl)N=C(Cl)N=C1NC1=CC=C(C2=CC=C(F)C=C2)C=C1 |
| Hazard Information | Back Directory | [Description]
KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth. | [Uses]
KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity[1]. | [in vivo]
KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth[1]. | Animal Model: | Immune-deficient SCID mice | | Dosage: | 5 mg/kg | | Administration: | I.p.; 50 days | | Result: | Attenuated tumor xenograft growth.
|
| [IC 50]
Caspase 3: 10 μM (IC50); Thioredoxin: 10 μM (IC50) | [storage]
4°C, protect from light | [References]
[1] Anderson KE, et al. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017;12(10):2522-2528. DOI:10.1021/acschembio.7b00711 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|