| Identification | Back Directory | [Name]
Benzenebutanamide, N-(3-methylbutyl)-α-[[3-[(4-methylphenyl)sulfonyl]-1-oxo-2-propen-1-yl]amino]-, (αS)- | [CAS]
2138924-36-2 | [Synonyms]
(S,E)-N-Isopentyl-4-phenyl-2-(3-tosylacrylamido)butanamide
Benzenebutanamide, N-(3-methylbutyl)-α-[[3-[(4-methylphenyl)sulfonyl]-1-oxo-2-propen-1-yl]amino]-, (αS)- | [Molecular Formula]
C25H32N2O4S | [MOL File]
2138924-36-2.mol | [Molecular Weight]
456.6 |
| Chemical Properties | Back Directory | [Boiling point ]
724.4±60.0 °C(Predicted) | [density ]
1.153±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.63±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells[1]. | [References]
[1] Tomlin FM, et al. Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity. ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. DOI:10.1021/acscentsci.7b00224 |
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