| Identification | Back Directory | [Name]
K-11777 | [CAS]
233277-99-1 | [Synonyms]
K-11777
4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide
1-Piperazinecarboxamide, 4-methyl-N-[(1S)-2-oxo-2-[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]-1-(phenylmethyl)ethyl]- | [Molecular Formula]
C32H38N4O4S | [MDL Number]
MFCD14105618 | [MOL File]
233277-99-1.mol | [Molecular Weight]
574.73 |
| Chemical Properties | Back Directory | [Boiling point ]
861.0±65.0 °C(Predicted) | [density ]
1.217±0.06 g/cm3(Predicted) | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
12.48±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
K777 Hydrochloride-d8 is the labelled analogue of K777 Hydrochloride (K165805). It acts as a cathespin B inhibitor which may be useful in the therapeutic treatment of Chagas’ disease. | [in vivo]
K777 (K11777; 35-105 mg/kg; oral administration; twice a day; for 10 days; C57BL/6 IFN-γR-KO mice) treatment rescues mice from otherwise lethal infections[4] . | Animal Model: | C57BL/6 IFN-γR-KO mice (6-8 weeks of age) injected with Cryptosporidium parvum[4] | | Dosage: | 35 mg/kg, 70 mg/kg, and 105 mg/kg | | Administration: | Oral administration; twice a day; for 10 days | | Result: | Rescued mice from otherwise lethal infections. |
| [IC 50]
CYP3; EBOV; MARV; CCR4; Trypanosoma |
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