| Identification | Back Directory | [Name]
2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)- | [CAS]
214287-90-8 | [Synonyms]
DMP963
DMP-963
DMP 963
2(1H)-Quinazolinone, 4-(2-cyclopropylethynyl)-5,6-difluoro-3,4-dihydro-4-(trifluoromethyl)-, (4S)- | [Molecular Formula]
C14H9F5N2O | [MOL File]
214287-90-8.mol | [Molecular Weight]
316.23 |
| Hazard Information | Back Directory | [Uses]
DPC-963 is an oral active non-nucleoside reverse transcriptase inhibitor with the IC50 of 18 nM. DPC-963 can be used for study of HIV[1][2]. | [References]
[1] Corbett JW, et al. Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1. Antimicrob Agents Chemother. 1999;43(12):2893-2897. DOI:10.1128/AAC.43.12.2893
[2] Corbett JW, et al. Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors. J Med Chem. 2000;43(10):2019-2030. DOI:10.1021/jm990580e |
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