| Identification | Back Directory | [Name]
Azidoethyl-PEG2-t-Butyl ester | [CAS]
2144777-83-1 | [Synonyms]
Azidoethyl-SS-PEG2-Boc
Azidoethyl-PEG2-t-Butyl ester | [Molecular Formula]
C13H25N3O4S2 | [MDL Number]
MFCD31561136 | [MOL File]
2144777-83-1.mol | [Molecular Weight]
351.48 |
| Hazard Information | Back Directory | [Description]
Azidoethyl-PEG2-t-Butyl ester is a PEG linker that contains a cleavable disulfide bond, an azide group and a t-butyl ester group. The disulfide bond can be cleaved via reduction reactions. The azide group can be reacted with an alkyne, DBCO or BCN moiety to undergo copper-catalyzed Click Chemistry. The t-butyl ester group can be removed under acidic conditions. | [Uses]
Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azidoethyl-SS-PEG2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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