| Identification | Back Directory | [Name]
Azido-PEG2-t-butyl ester | [CAS]
1271728-79-0 | [Synonyms]
N3-P2-SDZ
N3-P2-SDZ 1G
Azido-PEG2-C2-Boc
N3-PEG2-CH2CH2COOtBu
Azido-PEG2-t-butyl ester
N3-(CH2CH2O)2-CH2CH2COOt-Bu
tert-butyl 3-(2-(2-azidoethoxy)ethoxy)propanoate | [Molecular Formula]
C11H21N3O4 | [MDL Number]
MFCD20926379 | [MOL File]
1271728-79-0.mol | [Molecular Weight]
259.31 |
| Hazard Information | Back Directory | [Description]
Azido-PEG2- t-butyl ester is a azide containing PEG compound. The azide (N3) group is reactive with BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Azido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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