| Identification | Back Directory | [Name]
HS1371 | [CAS]
2158197-70-5 | [Synonyms]
HS1371
CS-2831
HS-1371; HS 1371; HS1371;2158197-70-5
Quinoline, 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- | [Molecular Formula]
C24H24N4O | [MDL Number]
MFCD31813738 | [MOL File]
2158197-70-5.mol | [Molecular Weight]
384.47 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMF:30.0(Max Conc. mg/mL);78.03(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.52(Max Conc. mM)
DMSO:11.56(Max Conc. mg/mL);30.06(Max Conc. mM)
Ethanol:4.5(Max Conc. mg/mL);11.7(Max Conc. mM) | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM[1]. | [Biological Activity]
HS1371 is a potent RIP3 kinase inhibitor with IC50 of 20.8 nM. It binds to the ATP-binding region of RIP3, thereby preventing ATP binding, inhibiting the enzymatic activity of RIP3 in vitro. | [in vitro]
HS1371 inhibits autorenal phosphorylation of RIP3 at S227. In HT-29 cells, it has full inhibitory activity on TNF-induced necroptosis signaling and is inactive on the phosphorylation of RIP3 and MLKL. It protects cells from RIP3-dependent necrotic cell death but does not affect apoptotic cell death. | [target]
| Target | Value | RIP3 kinase
() | 20.8 nM |
| [storage]
Store at -20°C | [References]
[1] Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125. DOI:10.1038/s12276-018-0152-8 |
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