| Identification | Back Directory | [Name]
PROTAC Mcl1 degrader-1 | [CAS]
2163793-38-0 | [Synonyms]
PROTAC Mcl1 degrader-1
Hexanediamide, N1-[2-[6-[(4-bromophenyl)thio]-1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl]ethyl]-N6-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]- | [Molecular Formula]
C45H45BrN6O8S | [MOL File]
2163793-38-0.mol | [Molecular Weight]
909.84 |
| Hazard Information | Back Directory | [Description]
Mcl-1 Degrader C3 is a novel potent and selective degrader of Mcl-1. | [Uses]
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM[1]. | [IC 50]
Mcl-1: 0.78 μM (IC50); Bcl-2: 0.54 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21. DOI:10.1021/acs.jmedchem.9b00919 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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