| Identification | Back Directory | [Name]
PROTAC MDM2 Degrader-2 | [CAS]
2249944-99-6 | [Synonyms]
PROTAC MDM2 Degrader-2
1-Piperazineacetamide, N,N'-[1,2-ethanediylbis(oxy-2,1-ethanediyl)]bis[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-, rel- | [Molecular Formula]
C70H76Cl4N10O12 | [MDL Number]
MFCD32197289 | [MOL File]
2249944-99-6.mol | [Molecular Weight]
1391.22 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 50 mg/mL (35.94 mM) | [form ]
Solid | [pka]
14.02±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase (CN108610333A)[1]. | [IC 50]
MDM2 | [References]
[1] Method of inducing of self-degradation of MDM2 using E3 ubiquitin ligase dimer amide small molecule PROTACs. CN108610333A. |
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