| Identification | Back Directory | [Name]
MCL-1/BCL-2-IN-2 | [CAS]
2163793-44-8 | [Synonyms]
MCL-1/BCL-2-IN-2
MCL1/BCL2IN2,MCL 1/BCL 2 IN 2
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2-aminoethyl)-6-[(4-bromophenyl)thio]- | [Molecular Formula]
C20H15BrN2O2S | [MOL File]
2163793-44-8.mol | [Molecular Weight]
427.31 |
| Chemical Properties | Back Directory | [Boiling point ]
630.9±50.0 °C(Predicted) | [density ]
1?+-.0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 5 mg/mL (11.70 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
8.68±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor[1]. | [storage]
Store at -20°C | [References]
[1] Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163. DOI:10.1021/acs.jmedchem.9b00919 |
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