| Identification | Back Directory | [Name]
BI-3812 | [CAS]
2166387-64-8 | [Synonyms]
BI-3812
CPD1815
BI3812;BI 3812
1-(5-Chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide
4-Piperidinecarboxamide, 1-[5-chloro-4-[[1,2-dihydro-8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-6-quinolinyl]amino]-2-pyrimidinyl]-N,N-dimethyl- | [Molecular Formula]
C26H32ClN7O5 | [MDL Number]
MFCD31657385 | [MOL File]
2166387-64-8.mol | [Molecular Weight]
558.03 |
| Chemical Properties | Back Directory | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:22.92(Max Conc. mg/mL);41.07(Max Conc. mM) | [form ]
Solid | [pka]
14.73±0.46(Predicted) | [color ]
Off-white to pink | [SMILES]
O=C1C(OCC(NC)=O)=CC2=C(N1C)C(OC)=CC(NC3=NC(N4CCC(CC4)C(N(C)C)=O)=NC=C3Cl)=C2 |
| Hazard Information | Back Directory | [Uses]
BI-3812 is a highly efficient BCL6 inhibitor that is capable of suppressing the BTB domain of BCL6, with an IC50 value of ≤ 3 nM, exhibiting antitumor activity[1]. | [Biological Activity]
BI-3812 is a potent BCL6 inhibitor with IC50 less than 3 nM. | [in vivo]
BI-3812 is a BCL6 inhibitor, with an IC 50 of ≤3 nM. BI-3812 shows an IC 50 of 40 nM for the cellular BCL6. | [target]
| Target | Value | BCL6
(Cell-free assay) | 3 nM |
| [References]
[1] Kerres N, et al. Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6. Cell Rep. 2017 Sep 19;20(12):2860-2875. DOI:10.1016/j.celrep.2017.08.081 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Twochem Co.Ltd
|
| Tel: |
021-021-58111628 15800915896 |
| Website: |
www.twochem.com |
|