| Chemical Properties | Back Directory | [density ]
1.316±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:61.14(Max Conc. mg/mL);54.96(Max Conc. mM)
Ethanol:22.27(Max Conc. mg/mL);20.02(Max Conc. mM) | [form ]
Solid | [pka]
9.35±0.20(Predicted) | [color ]
White to off-white | [InChIKey]
QUQTXFIMYFMULC-VOCJROMSNA-N |
| Hazard Information | Back Directory | [Uses]
dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24. | [Definition]
dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.
| [Biological Activity]
dTRIM24a conjugate of IACS-9571 a TRIM24 bromodomain ligand and VL-269 a VHL E3 ubiquitin ligase ligandis a selective bifunctional degrader of bromodomain-containing transcriptional regulator TRIM24 (transcriptional intermediary factor 1a). dTRIM24 induces rapid and sustain proteasome degradation of TRIM24 in 293FT cells. | [storage]
Store at -20°C | [References]
[1] Gechijian LN, et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat Chem Biol. 2018 Apr;14(4):405-412. DOI:10.1038/s41589-018-0010-y |
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