| Identification | Back Directory | [Name]
Benzoic acid, 4-[(4aR)-8-acetyl-4,4a-dihydro-5,7-dihydroxy-3,4a,6-trimethyl-4-oxo-1H-benzofuro[3,2-f]indazol-1-yl]- | [CAS]
2175953-98-5 | [Synonyms]
Tau-aggregation and neuroinflammation-IN-1
(R)-4-(8-Acetyl-5,7-dihydroxy-3,4a,6-trimethyl-4-oxo-4,4a-dihydro-1H-benzofuro[3,2-f]indazol-1-yl)benzoic acid
Benzoic acid, 4-[(4aR)-8-acetyl-4,4a-dihydro-5,7-dihydroxy-3,4a,6-trimethyl-4-oxo-1H-benzofuro[3,2-f]indazol-1-yl]- | [Molecular Formula]
C25H20N2O7 | [MOL File]
2175953-98-5.mol | [Molecular Weight]
460.44 |
| Chemical Properties | Back Directory | [Boiling point ]
770.6±60.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.74±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats[1]. | [in vivo]
Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; for 14 days) leads to a substantial improvement of the conventional reference spatial memory and cognitive abilities of OA-induced rats[1]. | Animal Model: | Male SD rats (250-270 g; OA was microinjected into the right dorsal hippocampus)[1] | | Dosage: | 5 and 10 mg/kg | | Administration: | IP; for 7 days, and after OA-injection continued IP for 7 days | | Result: | Led to a substantial improvement of the conventional reference spatial memory and cognitive abilities of rats. |
| [References]
[1] Shi CJ, Peng W, Zhao JH, et al. Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors. Eur J Med Chem. 2020;187:111961. DOI:10.1016/j.ejmech.2019.111961 |
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