| Chemical Properties | Back Directory | [density ]
1.466±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 1 mg/ml | [form ]
A crystalline solid | [pka]
7.44±0.20(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Description]
ARN19874 is an inhibitor of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD; IC50 = 33.7 μM). It is selective for NAPD-PLD over carbonic anhydrase II, neutral endopeptidase, and angiotensin-converting enzyme (ACE) up to 50 μM. ARN19874 (50 μM) increases the levels of certain NAPE substrates and decreases the endogenous levels of stearoyl ethanolamide , but not oleoyl ethanolamide or palmitoyl ethanolamide , in HEK293 cells. | [Uses]
ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor with an IC50 of ~34 μM[1]. | [References]
[1] Castellani B, et al. Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD). Chem Commun (Camb). 2017 Nov 28;53(95):12814-12817. DOI:10.1039/c7cc07582k |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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