| Identification | Back Directory | [Name]
AC-VEID-AMC | [CAS]
219137-97-0 | [Synonyms]
AC-VEID-MCA
AC-VEID-AMC
AC-VEID-AMC USP/EP/BP
AC-VAL-GLU-ILE-ASP-AMC
AC-VAL-GLU-ILE-ASP-MCA
CASPASE-6 SUBSTRATE (FLUOROGENIC)
CASPASE-6 SUBSTRATE I, FLUOROGENIC
CASPASE 6 (MCH2) SUBSTRATE 1M, FLUOROGENIC
Ac-Val-Glu-IIe-Asp-7-amino-4-methylcoumarin
AC-VAL-GLU-ILE-ASP-7-AMINO-4-METHYLCOUMARIN
N-ACETYL-VAL-GLU-ILE-ASP-7-AMINO-4-METHYLCOUMARIN AMC
ACETYL-L-VALYL-L-GLUTAMYL-L-ISOLEUCYL-L-ASPARTIC ACID ALPHA-(4-METHYLCOUMARYL-7-AMIDE) | [Molecular Formula]
C32H43N5O11 | [MDL Number]
MFCD01318831 | [MOL File]
219137-97-0.mol | [Molecular Weight]
673.71 |
| Chemical Properties | Back Directory | [Boiling point ]
1106.8±65.0 °C(Predicted) | [density ]
1.311±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C | [form ]
powder | [pka]
4.09±0.10(Predicted) | [color ]
white | [Appearance]
Solid Powder |
| Hazard Information | Back Directory | [Description]
Ac-VEID-AMC is a fluorogenic substrate for caspase-6 and related proteases including caspase-8. Caspase activity can be quantified by fluorescent detection of free AMC (7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. | [Uses]
Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm)[1]. | [References]
[1] Benford HL, et al. Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro. Bone. 2001 May;28(5):465-73. DOI:10.1016/s8756-3282(01)00412-4 | [Excitation / Emission Maximum]
340-360 nm/440-460 nm | [Sequene]
Ac-Val-Glu-Ile-Asp-AMC |
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