| Identification | Back Directory | [Name]
2-Pyridinamine, 6-[7-methoxy-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-N-3-pyrrolidinyl- | [CAS]
2193085-94-6 | [Synonyms]
2-Pyridinamine, 6-[7-methoxy-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-N-3-pyrrolidinyl- | [Molecular Formula]
C21H23N7O | [MOL File]
2193085-94-6.mol | [Molecular Weight]
389.45 |
| Hazard Information | Back Directory | [Uses]
NCGC1481 is an inhibitor of FLT3, IRAK1, and IRAK4, with IC50 values of <0.5 nM, 22.6 nM, and 0.8 nM, respectively. NCGC1481 can effectively overcome the adaptive resistance of leukemia cells to FLT3 inhibitors and has antileukemic activity[1]. | [References]
[1] Melgar K, et al. Overcoming adaptive therapy resistance in AML by targeting immune response pathways. Sci Transl Med. 2019 Sep 4;11(508):eaaw8828. DOI:10.1126/scitranslmed.aaw8828 |
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