| Identification | Back Directory | [Name]
Prolyl Hydroxylase inhibitor 1 | [CAS]
2205125-60-4 | [Synonyms]
Prolyl Hydroxylase inhibitor 1 | [Molecular Formula]
C19H18ClN5O4 | [MDL Number]
MFCD31813675 | [MOL File]
2205125-60-4.mol | [Molecular Weight]
415.83 |
| Hazard Information | Back Directory | [Uses]
Prolyl Hydroxylase inhibitor 1 (Compound 15i) is an orally active hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) inhibitor with an IC50 of 62.23 nM[1]. Antianemia agent[1]. | [References]
[1] Wu Y, et al. Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia. J Med Chem. 2018 Ju DOI:10.1021/acs.jmedchem.8b00549 |
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