| Identification | Back Directory | [Name]
Carbamic acid, (5-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI) | [CAS]
220731-04-4 | [Synonyms]
tert-Butyl (5-aminopyridin-2-yl)
tert-butyl 5-aminopyridin-2-ylcarbamate
ert-butylN-(5-aminopyridin-2-yl)carbamate
tert-Butyl N-(5-aminopyridin-2-yl)carbamate
Carbamic acid, (5-amino-2-pyridinyl)-, 1,1-dimethylethyl ester
Carbamic acid, N-(5-amino-2-pyridinyl)-, 1,1-dimethylethyl ester
Carbamic acid, (5-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C10H15N3O2 | [MDL Number]
MFCD11182697 | [MOL File]
220731-04-4.mol | [Molecular Weight]
209.24 |
| Chemical Properties | Back Directory | [Boiling point ]
330.2±27.0 °C(Predicted) | [density ]
1.202±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
12.19±0.70(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C10H15N3O2/c1-10(2,3)15-9(14)13-8-5-4-7(11)6-12-8/h4-6H,11H2,1-3H3,(H,12,13,14) | [InChIKey]
NHVPESPHUUFULF-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)NC1=NC=C(N)C=C1 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of tert-butyl (5-aminopyridin-2-yl)carbamate from tert-butyl (5-nitropyridin-2-yl)carbamate: tert-butyl (5-nitropyridin-2-yl)carbamate (1 eq.), 10% palladium carbon by weight of the raw material and ethyl acetate were added to a reaction flask under hydrogen atmosphere. The reaction mixture was stirred and reacted at room temperature overnight. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to give the target product tert-butyl (5-aminopyridin-2-yl)carbamate. The product was analyzed by HPLC-MS (Method A): retention time Rt = 1.50 min, molecular ion peak [M + H]+ m/z: 210. The reaction yield was quantitative. | [References]
[1] Patent: WO2016/120808, 2016, A1. Location in patent: Page/Page column 104
[2] Patent: US2010/249099, 2010, A1. Location in patent: Page/Page column 96
[3] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 54
[4] Patent: EP2518071, 2012, A1. Location in patent: Page/Page column 41-42
[5] Patent: WO2012/146667, 2012, A1. Location in patent: Page/Page column 95-96 |
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| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
skychemical Co.Ltd
|
| Telephone: |
021-20960837,QQ1332204249 |
| Website: |
http://www.skychemical.com |
| Company Name: |
Shanghai Bank Pharma Limited
|
| Telephone: |
2221346380 17701603001 |
| Website: |
www.chemicalbook.com/showsupplierproductslist20106/0_en.htm |
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