| Identification | Back Directory | [Name]
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3-one, 3',4',5',6'-tetrahydro-7,9,11,12,13,14,15-heptahydroxy-6'-(2-hydroxy-1-methylbutyl)-22-(2-hydroxypropyl)-5',6,8,16,28,29-hexamethyl-14-propyl-10-[(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)oxy]-, (4E,18E,20E)- (9CI) | [CAS]
220858-11-7 | [Synonyms]
Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3-one, 3',4',5',6'-tetrahydro-7,9,11,12,13,14,15-heptahydroxy-6'-(2-hydroxy-1-methylbutyl)-22-(2-hydroxypropyl)-5',6,8,16,28,29-hexamethyl-14-propyl-10-[(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)oxy]-, (4E,18E,20E)- (9CI) | [Molecular Formula]
C54H94O16 | [MOL File]
220858-11-7.mol | [Molecular Weight]
999.31 |
| Chemical Properties | Back Directory | [Boiling point ]
1016.9±65.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [solubility ]
Dichloromethane: soluble
DMSO: soluble
Ethanol: soluble
Methanol: soluble | [pka]
13.60±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
IB-96212 is a macrolide that has been found in Micromonospora and has antibacterial and anticancer activities.1 It is active against M. luteus, B. subtilis, and S. aureus (MICs = 0.4, 100, and 100 µg/ml, respectively). IB-96212 induces death in P388 leukemia, A549 lung cancer, HT-29 colon cancer, and SK-MEL-28 melanoma cells (IC50s = 0.0001, 1, 1, and 1 µg/ml, respectively).WARNING This product is not for human or veterinary use. | [References]
[1] R I FERNÁNDEZ-CHIMENO. IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation and biological activities.[J]. Journal of Antibiotics, 2000, 53 5: 474-478. DOI: 10.7164/antibiotics.53.474 |
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