| Identification | Back Directory | [Name]
EcGUS-IN-1 | [CAS]
2208619-76-3 | [Synonyms]
EcGUS-IN-1
Thiourea, N-1H-benzimidazol-6-yl-N′-[4-(trifluoromethyl)phenyl]- | [Molecular Formula]
C15H11F3N4S | [MOL File]
2208619-76-3.mol | [Molecular Weight]
336.34 |
| Chemical Properties | Back Directory | [Boiling point ]
517.7±60.0 °C(predicted) | [density ]
1.550±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
11.43±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
EcGUS-IN-1 (Compound E-9) is a non-competitive β-glucuronidase inhibitor, with an IC50 of 2.68 μM and a Ki value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli β-glucuronidase activity[1]. | [References]
[1] Xu K, et al. Design, synthesis, and biological evaluation of (thio)urea derivatives as potent Escherichia coli β-glucuronidase inhibitors. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2387415. DOI:10.1080/14756366.2024.2387415 |
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