| Identification | Back Directory | [Name]
2-Quinoxalinecarboxylic acid, 7-[4-[[[[(4-carboxyphenyl)amino]carbonyl]oxy]methyl]-1H-imidazol-1-yl]-3,4-dihydro-3-oxo-6-(trifluoromethyl)- | [CAS]
221164-28-9 | [Synonyms]
KRP-199
KRP199,KRP 199
2-Quinoxalinecarboxylic acid, 7-[4-[[[[(4-carboxyphenyl)amino]carbonyl]oxy]methyl]-1H-imidazol-1-yl]-3,4-dihydro-3-oxo-6-(trifluoromethyl)- | [Molecular Formula]
C22H14F3N5O7 | [MOL File]
221164-28-9.mol | [Molecular Weight]
517.37 |
| Hazard Information | Back Directory | [Uses]
KRP-199 (compound 14h) is an α-amino-3-hydroxy-5-methylisoxazolepropionic acid receptor (AMPA-R) antagonist (Ki=16 nM) with high potency and selectivity for AMPA-R in vitro and good neuroprotective effects in vivo. KRP-199 can be used in the study of neurodegenerative diseases[1]. | [References]
[1] Takano, et al. Design and synthesis of novel 7-heterocycle-6-trifluoromethyl-3-oxoquinoxaline-2-carboxylic acids bearing a substituted phenyl group as superior AMPA receptor antagonists with good physicochemical properties. Bioorganic & medicinal chemistry 14.3 (2006): 776-792. DOI:10.1016/j.bmc.2005.08.060 |
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