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2215768-12-8

2215768-12-8 Structure

2215768-12-8 Structure
IdentificationBack Directory
[Name]

Acetamide, 2-[[5-[(1-naphthalenyloxy)methyl]-4-(2-propen-1-yl)-4H-1,2,4-triazol-3-yl]thio]-N-2-thiazolyl-
[CAS]

2215768-12-8
[Synonyms]

Acetamide, 2-[[5-[(1-naphthalenyloxy)methyl]-4-(2-propen-1-yl)-4H-1,2,4-triazol-3-yl]thio]-N-2-thiazolyl-
[Molecular Formula]

C21H19N5O2S2
[MOL File]

2215768-12-8.mol
[Molecular Weight]

437.54
Chemical PropertiesBack Directory
[density ]

1.37±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

7.61±0.50(predicted)
Hazard InformationBack Directory
[Uses]

BChE-IN-34 is a potent and selective butyrylcholinesterase (BChE) inhibitor with an IIC50 of 25 nM. BChE-IN-34 shows excellent selectivity against BChE over acetylcholinesterase. BChE-IN-34 has neuroprotective and antioxidant effects[1].
[IC 50]

eqBCHE: 25 nM (IC50)
[References]

[1] Ebru Ko?ak Aslan, et al. Novel 1,2,4-triazole derivatives containing the naphthalene moiety as selective butyrylcholinesterase inhibitors: Design, synthesis, and biological evaluation. Arch Pharm (Weinheim). 2024 Jul 21:e2400406. DOI:10.1002/ardp.202400406
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