| Identification | Back Directory | [Name]
Rp-8-CPT-Cyclic AMP (sodium salt) | [CAS]
221905-35-7 | [Synonyms]
Rp-8-CPT-cAMPS sodium
VXMLCXRTUQHZAI-ALHPSJIMSA-N
Rp-8-CPT-Cyclic AMP (sodium salt)
Rp-8-CPT-Cyclic AMP sodium salt (Rp-8-CPT-cAMP) | [Molecular Formula]
C16H14ClN5NaO5PS2 | [MOL File]
221905-35-7.mol | [Molecular Weight]
509.859 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 0.5 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS . It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II. By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation. | [Uses]
Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS . It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II. By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[Cayman Chemical] | [storage]
Store at -20°C | [References]
[1] FRANK SCHWEDE . Cyclic nucleotide analogs as biochemical tools and prospective drugs[J]. Pharmacology & Therapeutics, 2000, 87 2: Pages 199-226. DOI: 10.1016/s0163-7258(00)00051-6
[2] W R DOSTMANN. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3’,5’-cyclic phosphorothioates.[J]. The Journal of Biological Chemistry, 1990, 265 18: 10484-10491.
[3] B T GJERTSEN. Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action.[J]. The Journal of Biological Chemistry, 1995, 270 35: 20599-20607. DOI: 10.1074/jbc.270.35.20599 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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