| Identification | Back Directory | [Name]
2-(2,6-DIOXOPIPERIDIN-3-YL)-5-FLUORO-6-(PIPERAZIN-1-YL)ISOINDOLINE-1,3-DIONE HCL | [CAS]
2222114-23-8 | [Synonyms]
2-(2,6-DIOXOPIPERIDIN-3-YL)-5-FLUORO-6-(PIPERAZIN-1-YL)ISOINDOLINE-1,3-DIONE HCL
2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(
piperazin-1-yl)isoindoline-1,3-dione
hydrochloride | [Molecular Formula]
C17H18ClFN4O4 | [MDL Number]
MFCD32203462 | [MOL File]
2222114-23-8.mol | [Molecular Weight]
396.8 |
| Hazard Information | Back Directory | [Description]
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride is a hydrochloride salt derivative of thalidomide with a flouride and piperazine groups on the benzyl ring. | [Uses]
Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis[1]. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. DOI:10.1038/nature13527 |
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