| Identification | Back Directory | [Name]
2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione | [CAS]
2098487-52-4 | [Synonyms]
Thalidomide-linker 5
E3 ligase Ligand-Linker Conjugates 32
2-(2,6-dioxopiperidin-3-yl)-4-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)isoindoline-1,3-dione
2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione | [Molecular Formula]
C20H20N2O7 | [MDL Number]
MFCD32063462 | [MOL File]
2098487-52-4.mol | [Molecular Weight]
400.38 |
| Chemical Properties | Back Directory | [Boiling point ]
629.2±55.0 °C(Predicted) | [density ]
1.374±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.69±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1]. Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
Thalidomide 4'-ether-PEG2-alkyne is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG2 linker with alkyne terminal ready for conjugation to a target protein ligand. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781 |
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